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KMID : 0385920010120010012
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Journal of the Korean Society of Emergency Medicine
2001 Volume.12 No. 1 p.12 ~ p.20
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Inhibition of Apoptosis Following Transient Forebrain Ischemia in Gerbils by Intraischemic Mild Hypothermia
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최승필/Choi SP
박규남/오동렬/박승현/김세경/유지영/이원재/천영호/Park KN/You JY/Park SH/Oh DR/Lee WJ/Chun YH/Kim SK
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Abstract
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BACKGROUND: A brief episode of global forebrain ischemia produces selective and often extensive neuronal loss in several vulnerable brain structures. This cell death does not occur immediately, but is delayed for hours to days. This process is termed delayed neuronal death (DND). Recently, several reports have suggested that an apoptotic process may be involved in DND. The most effective treatment at present is intraischemic hypothermia. Thus, we designed this study to investigate whether intraischemic mild hypothermia could inhibit apoptosis following transient forebrain ischemia in gerbils.
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KEYWORD
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Intraischemic hypothermia, Apoptosis, Transient brain ischemia
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